![]() In many cases, blisters can rupture becoming open sores or wounds. In autoimmune blistering diseases, blisters form because the body creates antibodies that attack certain proteins required for the proper health and function of the skin. Most blisters develop in response to irritation or injury of the skin. When the epidermis separates from the dermis a blister (bulla) may form.Ī blister can be either tiny or large and consists of a fluid-filled bubble that forms underneath the surface of damaged or dead skin. Specialized proteins and structures are required for the dermis and epidermis to stick together. #Massive boils bursting skinThe two main structural layers of the skin are the epidermis – the outermost, protective layer of skin – and the dermis – an underlying layer that contains numerous specialized cells, tissues and structures. Five distinct layers make up the skin each layer is filled with specialized cells. In addition to serving as a protective barrier, the skin is involved in many additional functions of the body such as regulating internal body temperature. The skin is the largest organ of the body. For more information, choose the specific disease name as your search term in the Rare Disease Database. NORD has individual reports on many of the specific disorders classified as autoimmune blistering diseases. In recent years, new insight into the causes and development of these disorders has led to research into new therapies such as the development of drugs that target the specific antibodies which cause the symptoms of these diseases. In other cases, autoimmune blistering diseases if left untreated can eventually cause life-threatening complications. Although there is no cure for autoimmune blistering diseases, they can often be controlled with treatment. In some cases, blistering lesions can cover a significant portion of the skin. The specific symptoms and severity of blistering diseases vary from one person to another, even among individuals with the same disorder. In autoimmune blistering diseases, antibodies erroneously attack proteins that are essential for the layers of skin to stick (adhere) together. 5 Myths About Orphan Drugs and the Orphan Drug ActĪutoimmune blistering diseases are a group of disorders in which the body mistakenly attacks healthy tissue, causing blistering lesions that primarily affect the skin and mucous and membranes.Information on Clinical Trials and Research Studies. ![]()
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